That may be the S. S. California, which made regular trips from the East Coast to the West Coast via the Panama Canal.  I don't know what year this is.  Almost all of those cars look like '32 Fords to me.  I can almost recognize the work of iconic San Diego photographer Lee Passmore, whose slogan was "You may pass more photographers, but no more like Passmore."

Go figure!!  It's still a Cruise Ship Terminal.